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KMID : 0613820120220070950
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Journal of Life Science
2012 Volume.22 No. 7 p.950 ~ p.957
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Antioxidant and Antiobesity Activity of Solvent Fractions from Red Garlic
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Hwang Cho-Rong
Shin Jung-Hae
Kang Min-Jung
Lee Soo-Jung
Sung Nak-Ju
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Abstract
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Development of garlic processing products by thermal treatment and researched biological activity of a new product, red garlic. Red garlic MeOH extract was graduated by solvents, such as hexane, chloroform, ethyl acetate, butanol, and water, in order. Each solvent fraction was dried by a rotary evaporator and then resolved in water for analysis of its antioxidant and antiobesity activity. Browning compounds of red garlic fractions were the highest in the chloroform fraction. Total phenolic compounds and flavonoid content were highest in the hexane fraction. The chloroform fraction showed significantly higher activity in DPPH, ABTS radical scavenging activity, and antioxidant activity by FRAP. We propose that the antioxidant activity of the solvent fractions from red garlic was revealed interaction of browning compounds, total phenolic compounds, and flavonoids. Due to the higher activity of the shown fraction, the hexane and the chloroform fractions were have high contents of these compounds. Below 500μg/ml, pancreatic lipase inhibition activity was significantly increased by sample concentration. And chloroform fraction, have the highest inhibition activity was shown over the 40%. In 3T3-L1 cells, the lipid accumulation inhibition activity was lower in the hexane and in the chloroform fraction than in the other fractions.
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KEYWORD
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Red garlic, solvent fraction, antioxidant activity, anti-obesity activity
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